InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CYCS

Summary

InnateDB Protein

IDBP-701754.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYCS

Protein Name

Cytochrome c

Synonyms

cytc;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000051780

InnateDB Gene

IDBG-649069 (CYCS)

Protein Structure

UniProt Annotation

Function

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0009055	electron carrier activity
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0070469	respiratory chain

Protein Structure and Domains

PDB ID

InterPro

IPR002327 Cytochrome c, class IA/ IB
IPR003088 Cytochrome c domain
IPR009056 Cytochrome c-like domain

PFAM

PF00034
PF13442

PRINTS

PR00604

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P62894

PhosphoSite

PhosphoSite-P62894

TrEMBL

UniProt Splice Variant

Entrez Gene

510767

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC105397

GenPept

AAI05398