InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HIST4H4

Summary

InnateDB Protein

IDBP-597404.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIST4H4

Protein Name

histone cluster 4, H4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000443017

InnateDB Gene

IDBG-21047 (HIST4H4)

Protein Structure

UniProt Annotation

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Note=Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 157 experimentally validated interaction(s) in this database.

Experimentally validated
Total	157 [view]
Protein-Protein	134 [view]
Protein-DNA	22 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0035575	histone demethylase activity (H4-K20 specific)
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0000723	telomere maintenance
GO:0006325	chromatin organization
GO:0006334	nucleosome assembly
GO:0006335	DNA replication-dependent nucleosome assembly
GO:0006336	DNA replication-independent nucleosome assembly
GO:0006352	DNA-templated transcription, initiation
GO:0034080	centromere-specific nucleosome assembly
GO:0035574	histone H4-K20 demethylation
GO:0045653	negative regulation of megakaryocyte differentiation
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0000228	nuclear chromosome
GO:0000786	nucleosome
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016020	membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome