InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPB41L3

Summary

InnateDB Protein

IDBP-595003.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPB41L3

Protein Name

erythrocyte membrane protein band 4.1-like 3

Synonyms

4.1B; DAL-1; DAL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000442091

InnateDB Gene

IDBG-527 (EPB41L3)

Protein Structure

UniProt Annotation

Function

Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N- methyltransferases, including PRMT3 and PRMT5. {ECO:0000269PubMed:15334060, ECO:0000269PubMed:15737618, ECO:0000269PubMed:16420693, ECO:0000269PubMed:9892180}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction {ECO:0000269PubMed:9892180}. Cell membrane {ECO:0000269PubMed:9892180}; Peripheral membrane protein {ECO:0000269PubMed:9892180}; Cytoplasmic side {ECO:0000269PubMed:9892180}. Cytoplasm {ECO:0000269PubMed:9892180}. Note=Detected in the cytoplasm of actively dividing cells.

Disease Associations

Tissue Specificity

Expressed at high levels in brain, with lower levels in kidney, intestine, and testis. Detected in lung. {ECO:0000269PubMed:9892180}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding

Biological Process

GO:0002175	protein localization to paranode region of axon
GO:0006915	apoptotic process
GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0008150	biological_process
GO:0008360	regulation of cell shape
GO:0030865	cortical cytoskeleton organization
GO:0030866	cortical actin cytoskeleton organization
GO:0030913	paranodal junction assembly
GO:0043217	myelin maintenance
GO:0048812	neuron projection morphogenesis
GO:0071205	protein localization to juxtaparanode region of axon
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0019898	extrinsic component of membrane
GO:0030673	axolemma
GO:0033270	paranode region of axon
GO:0044224	juxtaparanode region of axon

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR000798 Ezrin/radixin/moesin like
IPR007477 SAB domain
IPR008379 Band 4.1, C-terminal
IPR014847 FERM adjacent (FA)
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR021187 Band 4.1 protein
IPR029071 Ubiquitin-related domain

PFAM

PF04382
PF05902
PF08736
PF09379
PF09380
PF00373

PRINTS

PR00661
PR00935

PIRSF

PIRSF002304

SMART

SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References