InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PNN

Summary

InnateDB Protein

IDBP-5269.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PNN

Protein Name

pinin, desmosome associated protein

Synonyms

DRS; DRSP; memA; SDK3;

Species

Homo sapiens

Ensembl Protein

ENSP00000216832

InnateDB Gene

IDBG-5267 (PNN)

Protein Structure

UniProt Annotation

Function

Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell- cell adhesion. Potential tumor suppressor for renal cell carcinoma. {ECO:0000269PubMed:12051732, ECO:0000269PubMed:14517304, ECO:0000269PubMed:15542832, ECO:0000269PubMed:15735603, ECO:0000269PubMed:22388736}.

Subcellular Localization

Nucleus speckle. Cell junction, desmosome. Note=Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.

Disease Associations

Tissue Specificity

Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors. {ECO:0000269PubMed:10095061, ECO:0000269PubMed:8922384, ECO:0000269PubMed:9447706}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.

Experimentally validated
Total	53 [view]
Protein-Protein	53 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005198	structural molecule activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007155	cell adhesion

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005882	intermediate filament
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0030057	desmosome
GO:0035145	exon-exon junction complex
GO:0071013	catalytic step 2 spliceosome