InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDS5A

Summary

InnateDB Protein

IDBP-484187.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDS5A

Protein Name

PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)

Synonyms

SCC-112; SCC112;

Species

Homo sapiens

Ensembl Protein

ENSP00000426749

InnateDB Gene

IDBG-14730 (PDS5A)

Protein Structure

UniProt Annotation

Function

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269PubMed:15855230, ECO:0000269PubMed:19907496}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11076961, ECO:0000269PubMed:15019998}. Note=Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase. {ECO:0000269PubMed:11076961, ECO:0000269PubMed:15019998}.

Disease Associations

Tissue Specificity

Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue. Isoform 2 is expressed in kidney. {ECO:0000269PubMed:15019998}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	53 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0008156	negative regulation of DNA replication

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005829	cytosol
GO:0005886	plasma membrane