InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Oxct1

Summary

InnateDB Protein

IDBP-259724.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Oxct1

Protein Name

3-oxoacid CoA transferase 1

Synonyms

2610008O03Rik; Oxct; Oxct2a; Scot-s;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106318

InnateDB Gene

IDBG-127912 (Oxct1)

Protein Structure

UniProt Annotation

Function

Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008260	3-oxoacid CoA-transferase activity
GO:0008410	CoA-transferase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0007420	brain development
GO:0007507	heart development
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0009725	response to hormone
GO:0014823	response to activity
GO:0032024	positive regulation of insulin secretion
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042182	ketone catabolic process
GO:0042493	response to drug
GO:0042594	response to starvation
GO:0045471	response to ethanol
GO:0046950	cellular ketone body metabolic process
GO:0046952	ketone body catabolic process
GO:0060612	adipose tissue development
GO:0071229	cellular response to acid
GO:0071333	cellular response to glucose stimulus

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:1914291

InterPro

IPR004165 Coenzyme A transferase family I
IPR012791 3-oxoacid CoA-transferase, subunit B
IPR012792 3-oxoacid CoA-transferase, subunit A
IPR014388 3-oxoacid CoA-transferase

PFAM

PF01144

PRINTS

PIRSF

PIRSF000858

SMART

SM00882

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt