InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NDRG2

Summary

InnateDB Protein

IDBP-2448.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDRG2

Protein Name

NDRG family member 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000344620

InnateDB Gene

IDBG-2444 (NDRG2)

Protein Structure

UniProt Annotation

Function

Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. {ECO:0000269PubMed:12845671, ECO:0000269PubMed:16103061, ECO:0000269PubMed:21247902}.

Subcellular Localization

Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone {ECO:0000250}. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level). {ECO:0000269PubMed:11352569, ECO:0000269PubMed:11936845, ECO:0000269PubMed:12845671, ECO:0000269PubMed:14572661, ECO:0000269PubMed:15207261, ECO:0000269PubMed:15526377, ECO:0000269PubMed:16103061}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0016055	Wnt signaling pathway
GO:0021762	substantia nigra development
GO:0030154	cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0030426	growth cone
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome