InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TYMP

Summary

InnateDB Protein

IDBP-239057.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TYMP

Protein Name

thymidine phosphorylase

Synonyms

ECGF; ECGF1; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PDECGF; TP;

Species

Homo sapiens

Ensembl Protein

ENSP00000379038

InnateDB Gene

IDBG-13815 (TYMP)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004645	phosphorylase activity
GO:0005161	platelet-derived growth factor receptor binding
GO:0008083	growth factor activity
GO:0009032	thymidine phosphorylase activity
GO:0016154	pyrimidine-nucleoside phosphorylase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0016763	transferase activity, transferring pentosyl groups

Biological Process

GO:0000002	mitochondrial genome maintenance
GO:0001525	angiogenesis
GO:0006206	pyrimidine nucleobase metabolic process
GO:0006213	pyrimidine nucleoside metabolic process
GO:0006220	pyrimidine nucleotide metabolic process
GO:0006260	DNA replication
GO:0006935	chemotaxis
GO:0008152	metabolic process
GO:0030154	cell differentiation
GO:0043097	pyrimidine nucleoside salvage
GO:0044281	small molecule metabolic process
GO:0046135	pyrimidine nucleoside catabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000053 Pyrimidine-nucleoside phosphorylase
IPR000312 Glycosyl transferase, family 3
IPR013102 Pyrimidine nucleoside phosphorylase, C-terminal
IPR017459 Glycosyl transferase family 3, N-terminal domain
IPR018090 Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic

PFAM

PF00591
PF07831
PF02885

PRINTS

PIRSF

PIRSF000478

SMART

SM00941

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt