InnateDB Protein
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IDBP-234260.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NDRG2
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Protein Name
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NDRG family member 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380943
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InnateDB Gene
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IDBG-2444 (NDRG2)
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Protein Structure
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Function |
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. {ECO:0000269PubMed:12845671, ECO:0000269PubMed:16103061, ECO:0000269PubMed:21247902}.
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Subcellular Localization |
Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone {ECO:0000250}. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level). {ECO:0000269PubMed:11352569, ECO:0000269PubMed:11936845, ECO:0000269PubMed:12845671, ECO:0000269PubMed:14572661, ECO:0000269PubMed:15207261, ECO:0000269PubMed:15526377, ECO:0000269PubMed:16103061}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004142
NDRG
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF03096
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UN36
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PhosphoSite |
PhosphoSite-Q9UN36
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TrEMBL |
G3V5V9
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UniProt Splice Variant |
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Entrez Gene |
57447
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UniGene |
Hs.525205
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RefSeq |
NP_001269141
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HUGO |
HGNC:14460
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OMIM |
605272
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CCDS |
CCDS73613
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HPRD |
17630
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IMGT |
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EMBL |
AB033074
AF159092
AF304051
AK096999
AK293514
AL136574
AL161668
AY028430
BC010458
BC011240
BC093038
BX247987
BX248031
CH471078
CR749252
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GenPept |
AAD43131
AAH10458
AAH11240
AAH93038
AAK50340
AAL08624
BAA86562
BAG53405
BAG56997
CAB66509
CAD62321
CAD62350
CAH18108
EAW66422
EAW66423
EAW66424
EAW66425
EAW66426
EAW66427
EAW66428
EAW66429
EAW66430
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