InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRSF1

Summary

InnateDB Protein

IDBP-22737.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRSF1

Protein Name

G-rich RNA sequence binding factor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000254799

InnateDB Gene

IDBG-22735 (GRSF1)

Protein Structure

UniProt Annotation

Function

Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences. {ECO:0000269PubMed:23473033, ECO:0000269PubMed:23473034}.

Subcellular Localization

Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Note=Forms granules that colocalize with foci of newly synthesized mtRNA next to mitochondrial nucleoids.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.

Experimentally validated
Total	50 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006378	mRNA polyadenylation
GO:0008033	tRNA processing
GO:0009952	anterior/posterior pattern specification
GO:0016331	morphogenesis of embryonic epithelium