InnateDB Protein
|
IDBP-21924.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
SULT1B1
|
Protein Name
|
sulfotransferase family, cytosolic, 1B, member 1
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000308770
|
InnateDB Gene
|
IDBG-21922 (SULT1B1)
|
Protein Structure
|
|
Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine. {ECO:0000269PubMed:9443824, ECO:0000269PubMed:9463486}.
|
Subcellular Localization |
Cytoplasm {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) and spleen. A lesser expression was observed in the lung, placenta and thymus. {ECO:0000269PubMed:9463486}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000863
Sulfotransferase domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
|
PFAM |
PF00685
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O43704
|
PhosphoSite |
PhosphoSite-O43704
|
TrEMBL |
D6RIA8
|
UniProt Splice Variant |
|
Entrez Gene |
27284
|
UniGene |
Hs.129742
|
RefSeq |
NP_055280
|
HUGO |
HGNC:17845
|
OMIM |
608436
|
CCDS |
CCDS3530
|
HPRD |
07088
|
IMGT |
|
EMBL |
AC108941
AC125239
AF184894
BC010895
D89479
U95726
|
GenPept |
AAB65154
AAF05917
AAH10895
BAA24547
|
|
|