Homo sapiens Protein: LIMK1 | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Protein | IDBP-20947.6 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | LIMK1 | ||||||||||||||||||||||||||
Protein Name | LIM domain kinase 1 | ||||||||||||||||||||||||||
Synonyms | LIMK; LIMK-1; | ||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||
Ensembl Protein | ENSP00000336740 | ||||||||||||||||||||||||||
InnateDB Gene | IDBG-20945 (LIMK1) | ||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||
Function | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin- 2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). {ECO:0000269PubMed:10196227, ECO:0000269PubMed:10436159, ECO:0000269PubMed:11832213, ECO:0000269PubMed:12807904, ECO:0000269PubMed:15660133, ECO:0000269PubMed:16230460, ECO:0000269PubMed:18028908, ECO:0000269PubMed:23633677}. | ||||||||||||||||||||||||||
Subcellular Localization | Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm. | ||||||||||||||||||||||||||
Disease Associations | Note=LIMK1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. | ||||||||||||||||||||||||||
Tissue Specificity | Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle. | ||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR001478 PDZ domain IPR001781 Zinc finger, LIM-type IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR010440 Lipopolysaccharide kinase IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF07714 PF00595 PF13180 PF00412 PF06293 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||||||||
SMART |
SM00228
SM00132 SM00220 SM00219 |
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TIGRFAMs | |||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | P53667 | ||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-P53667 | ||||||||||||||||||||||||||
TrEMBL | Q75MU4 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 3984 | ||||||||||||||||||||||||||
UniGene | Hs.650078 | ||||||||||||||||||||||||||
RefSeq | NP_002305 | ||||||||||||||||||||||||||
HUGO | HGNC:6613 | ||||||||||||||||||||||||||
OMIM | 601329 | ||||||||||||||||||||||||||
CCDS | CCDS5563 | ||||||||||||||||||||||||||
HPRD | 03210 | ||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | AC005056 AC005057 AF134379 AK300382 CH471200 D26309 U62293 U63721 | ||||||||||||||||||||||||||
GenPept | AAB17545 AAB17546 AAC13885 AAC13886 AAD25742 AAS07436 AAS07438 BAA05371 BAH13274 EAW69620 EAW69621 EAW69622 EAW69623 | ||||||||||||||||||||||||||