InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNX18

Summary

InnateDB Protein

IDBP-20658.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNX18

Protein Name

sorting nexin 18

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000317332

InnateDB Gene

IDBG-20654 (SNX18)

Protein Structure

UniProt Annotation

Function

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. {ECO:0000269PubMed:18411244, ECO:0000269PubMed:20427313, ECO:0000269PubMed:21048941, ECO:0000269PubMed:22718350}.

Subcellular Localization

Endomembrane system; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized with clathrin and dynamin at the cell membrane. Transiently recruited to clathrin- coated pits at a late stage of clathrin-coated vesicle formation.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0007067	mitotic nuclear division
GO:0015031	protein transport
GO:0016197	endosomal transport
GO:0036089	cleavage furrow formation
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005768	endosome
GO:0010008	endosome membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030136	clathrin-coated vesicle
GO:0030426	growth cone
GO:0030659	cytoplasmic vesicle membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR001683 Phox homologous domain
IPR011511 Variant SH3 domain
IPR014536 Sorting nexin 9 subfamily
IPR019497 Sorting nexin protein, WASP-binding domain

PFAM

PF00018
PF14604
PF00787
PF07653
PF10456

PRINTS

PR00452

PIRSF

PIRSF027744

SMART

SM00326
SM00312

TIGRFAMs

Post-translational Modifications

Modification

Cross-References