InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tymp

Summary

InnateDB Protein

IDBP-173925.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tymp

Protein Name

thymidine phosphorylase

Synonyms

2900072D10Rik; Ecgf1; PD-ECGF; PDECGF; Pdgfec;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023285

InnateDB Gene

IDBG-173923 (Tymp)

Protein Structure

UniProt Annotation

Function

Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004645	phosphorylase activity
GO:0009032	thymidine phosphorylase activity
GO:0016154	pyrimidine-nucleoside phosphorylase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0016763	transferase activity, transferring pentosyl groups

Biological Process

GO:0006206	pyrimidine nucleobase metabolic process
GO:0006213	pyrimidine nucleoside metabolic process
GO:0006935	chemotaxis
GO:0008152	metabolic process
GO:0009887	organ morphogenesis

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1920212

InterPro

IPR000053 Pyrimidine-nucleoside phosphorylase
IPR000312 Glycosyl transferase, family 3
IPR013102 Pyrimidine nucleoside phosphorylase, C-terminal
IPR017459 Glycosyl transferase family 3, N-terminal domain
IPR018090 Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic

PFAM

PF00591
PF07831
PF02885

PRINTS

PIRSF

PIRSF000478

SMART

SM00941

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt