InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnrc6b

Summary

InnateDB Protein

IDBP-163943.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnrc6b

Protein Name

trinucleotide repeat containing 6b

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064336

InnateDB Gene

IDBG-163941 (Tnrc6b)

Protein Structure

UniProt Annotation

Function

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000250}. Note=Mammalian P-bodies are also known as GW bodies (GWBs). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006417	regulation of translation
GO:0031047	gene silencing by RNA
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay