InnateDB Protein
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IDBP-14885.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TCF3
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Protein Name
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transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
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Synonyms
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bHLHb21; E2A; E47; ITF1; TCF-3; VDIR;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000344375
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InnateDB Gene
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IDBG-14881 (TCF3)
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Protein Structure
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Function |
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.
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Subcellular Localization |
Nucleus.
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Disease Associations |
Note=Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1. TCF3-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family. Translocation t(17;19)(q22;p13.3) with HLF. Inversion inv(19)(p13;q13) with TFPT.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 188 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
99 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0001078
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0003713
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transcription coactivator activity
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GO:0005515
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protein binding
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GO:0008134
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transcription factor binding
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GO:0031435
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mitogen-activated protein kinase kinase kinase binding
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GO:0035326
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enhancer binding
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GO:0042803
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protein homodimerization activity
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GO:0043425
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bHLH transcription factor binding
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GO:0043565
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sequence-specific DNA binding
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GO:0044212
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transcription regulatory region DNA binding
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GO:0046982
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protein heterodimerization activity
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GO:0046983
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protein dimerization activity
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GO:0070491
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repressing transcription factor binding
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GO:0070644
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vitamin D response element binding
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GO:0070888
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E-box binding
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0002326
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B cell lineage commitment
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0030183
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B cell differentiation
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GO:0030890
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positive regulation of B cell proliferation
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GO:0033152
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immunoglobulin V(D)J recombination
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GO:0042692
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muscle cell differentiation
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GO:0045666
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positive regulation of neuron differentiation
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GO:0045787
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positive regulation of cell cycle
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0051091
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positive regulation of sequence-specific DNA binding transcription factor activity
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GO:0051149
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positive regulation of muscle cell differentiation
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GO:2000045
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regulation of G1/S transition of mitotic cell cycle
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Cellular Component |
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PDB ID |
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
P15923
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PhosphoSite |
PhosphoSite-P15923
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TrEMBL |
B1NYC3
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UniProt Splice Variant |
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Entrez Gene |
6929
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UniGene |
Hs.741355
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RefSeq |
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HUGO |
HGNC:11633
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OMIM |
147141
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CCDS |
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HPRD |
00918
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IMGT |
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EMBL |
AC005321
AC006274
BC110579
EU159436
M24404
M24405
M31222
M31522
M31523
M65214
X52078
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GenPept |
AAA36764
AAA52331
AAA56829
AAA56830
AAA61146
AAC27373
AAC41693
AAC99797
AAI10580
ACB05872
CAA36297
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