Version 5.4
Homo sapiens Protein: DAP
Summary
InnateDB Protein IDBP-12513.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAP
Protein Name death-associated protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000230895
InnateDB Gene IDBG-12509 (DAP)
Protein Structure
UniProt Annotation
Function Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death. {ECO:0000269PubMed:20537536}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0070513 death domain binding
Biological Process
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010507 negative regulation of autophagy
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034198 cellular response to amino acid starvation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0097190 apoptotic signaling pathway
Cellular Component
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51397
PhosphoSite PhosphoSite-P51397
TrEMBL
UniProt Splice Variant
Entrez Gene 1611
UniGene Hs.75189
RefSeq NP_004385
HUGO HGNC:2672
OMIM 600954
CCDS CCDS3880
HPRD 02977
IMGT
EMBL AY266680 BC002726 CR542184 X76105
GenPept AAH02726 AAO89078 CAA53713 CAG46981

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca