InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DLST

Summary

InnateDB Protein

IDBP-12476.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLST

Protein Name

dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)

Synonyms

DLTS;

Species

Homo sapiens

Ensembl Protein

ENSP00000335304

InnateDB Gene

IDBG-12474 (DLST)

Protein Structure

UniProt Annotation

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004149	dihydrolipoyllysine-residue succinyltransferase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0006099	tricarboxylic acid cycle
GO:0006554	lysine catabolic process
GO:0008152	metabolic process
GO:0033512	L-lysine catabolic process to acetyl-CoA via saccharopine
GO:0034641	cellular nitrogen compound metabolic process
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0016020	membrane
GO:0045252	oxoglutarate dehydrogenase complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000089 Biotin/lipoyl attachment
IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR006255 Dihydrolipoamide succinyltransferase
IPR011053 Single hybrid motif

PFAM

PF00364
PF00198

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P36957

PhosphoSite