InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC34A2

Summary

InnateDB Protein

IDBP-12389.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC34A2

Protein Name

solute carrier family 34 (sodium phosphate), member 2

Synonyms

NAPI-3B; NAPI-IIb; NPTIIb;

Species

Homo sapiens

Ensembl Protein

ENSP00000371483

InnateDB Gene

IDBG-12387 (SLC34A2)

Protein Structure

UniProt Annotation

Function

May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Pulmonary alveolar microlithiasis (PALM) [MIM:265100]: Rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early-onset or rapid progression are rare. A 'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long- term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance. {ECO:0000269PubMed:16960801}. Note=The disease is caused by mutations affecting the gene represented in this entry.Note=A chromosomal aberration involving SLC34A2 is found in a glioblastoma multiforme cell line U-118MG. Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity. {ECO:0000269PubMed:12661006}.

Tissue Specificity

Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium. {ECO:0000269PubMed:10329428, ECO:0000269PubMed:10610722}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005436	sodium:phosphate symporter activity
GO:0005524	ATP binding
GO:0015321	sodium-dependent phosphate transmembrane transporter activity
GO:0019904	protein domain specific binding
GO:0031402	sodium ion binding
GO:0042301	phosphate ion binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0001701	in utero embryonic development
GO:0006810	transport
GO:0006811	ion transport
GO:0006817	phosphate ion transport
GO:0007568	aging
GO:0009750	response to fructose
GO:0030643	cellular phosphate ion homeostasis
GO:0032355	response to estradiol
GO:0035435	phosphate ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0043627	response to estrogen
GO:0044341	sodium-dependent phosphate transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005903	brush border
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0031528	microvillus membrane