InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRAP1

Summary

InnateDB Protein

IDBP-12292.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRAP1

Protein Name

TNF receptor-associated protein 1

Synonyms

HSP 75; HSP75; HSP90L; TRAP-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000246957

InnateDB Gene

IDBG-12290 (TRAP1)

Protein Structure

UniProt Annotation

Function

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269PubMed:23525905, ECO:0000269PubMed:23564345, ECO:0000269PubMed:23747254}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:23564345}. Mitochondrion inner membrane {ECO:0000269PubMed:23564345}. Mitochondrion matrix {ECO:0000269PubMed:23564345}.

Disease Associations

Tissue Specificity

Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors. {ECO:0000269PubMed:23564345}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	61 [view]
Protein-Protein	59 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0006950	response to stress
GO:1901856	negative regulation of cellular respiration
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0005759	mitochondrial matrix
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001404 Heat shock protein Hsp90 family
IPR003594 Histidine kinase-like ATPase, C-terminal domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR020575 Heat shock protein Hsp90, N-terminal

PFAM

PF00183
PF02518
PF13581

PRINTS

PR00775

PIRSF

PIRSF002583

SMART

SM00387

TIGRFAMs

Post-translational Modifications

Modification

Cross-References