InnateDB Protein
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IDBP-10124.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HNRNPA2B1
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Protein Name
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heterogeneous nuclear ribonucleoprotein A2/B1
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Synonyms
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HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1; IBMPFD2; RNPA2; SNRPB1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000346694
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InnateDB Gene
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IDBG-10118 (HNRNPA2B1)
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Protein Structure
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Function |
Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus.
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Subcellular Localization |
Nucleus, nucleoplasm {ECO:0000269PubMed:17289661}. Cytoplasm {ECO:0000269PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Predominantly nucleoplasmic, however isoform A2 is also found in the cytoplasm of cells in some tissues. Not found in the nucleolus.
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Disease Associations |
Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2 (IBMPFD2) [MIM:615422]: An autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance. {ECO:0000269PubMed:23455423}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 174 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
174
[view]
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Protein-Protein |
169
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
IPR021662
Nuclear factor hnRNPA1
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PFAM |
PF00076
PF11627
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
P22626
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PhosphoSite |
PhosphoSite-P22626
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TrEMBL |
A0A024RA61
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UniProt Splice Variant |
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Entrez Gene |
3181
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UniGene |
Hs.706166
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RefSeq |
NP_112533
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HUGO |
HGNC:5033
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OMIM |
600124
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CCDS |
CCDS43557
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HPRD |
02526
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IMGT |
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EMBL |
AK289429
CH471073
D28877
M29064
M29065
U09120
U09121
U09122
U09123
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GenPept |
AAA36574
AAA60271
AAB60650
BAA06031
BAA06032
BAF82118
EAW93837
EAW93838
EAW93839
EAW93840
EAW93841
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