InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNRNPA2B1

Summary

InnateDB Protein

IDBP-10122.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPA2B1

Protein Name

heterogeneous nuclear ribonucleoprotein A2/B1

Synonyms

HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1; IBMPFD2; RNPA2; SNRPB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000354021

InnateDB Gene

IDBG-10118 (HNRNPA2B1)

Protein Structure

UniProt Annotation

Function

Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000269PubMed:17289661}. Cytoplasm {ECO:0000269PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Predominantly nucleoplasmic, however isoform A2 is also found in the cytoplasm of cells in some tissues. Not found in the nucleolus.

Disease Associations

Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2 (IBMPFD2) [MIM:615422]: An autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance. {ECO:0000269PubMed:23455423}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 174 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	174 [view]
Protein-Protein	169 [view]
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0043047	single-stranded telomeric DNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0050658	RNA transport

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0071013	catalytic step 2 spliceosome