InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IFT140

Summary

InnateDB Gene

IDBG-9054.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFT140

Gene Name

intraflagellar transport 140 homolog (Chlamydomonas)

Synonyms

c305C8.4; c380F5.1; gs114; MZSDS; SRTD9; WDTC2

Species

Homo sapiens

Ensembl Gene

ENSG00000187535

Encoded Proteins

IDBP-9056

intraflagellar transport 140 homolog (Chlamydomonas)

IDBP-235400

intraflagellar transport 140 homolog (Chlamydomonas)

IDBP-363263

intraflagellar transport 140 homolog (Chlamydomonas)

IDBP-745201

IDBP-749882

IDBP-746534

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease. [provided by RefSeq, Jun 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:1510427-1612110

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000361339	ENSP00000354895
ENST00000397417	ENSP00000380562
ENST00000426508	ENSP00000406012
ENST00000439987
ENST00000568837	ENSP00000458439
ENST00000561954
ENST00000566818
ENST00000566052
ENST00000569812	ENSP00000457092
ENST00000565298
ENST00000569646	ENSP00000454781

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0042384	cilium assembly
GO:0048705	skeletal system morphogenesis
GO:0060041	retina development in camera-type eye
GO:0060271	cilium morphogenesis
GO:0061512	protein localization to cilium
GO:0072001	renal system development
GO:1902017	regulation of cilium assembly

Cellular Component

GO:0005813	centrosome
GO:0005929	cilium
GO:0005930	axoneme
GO:0030991	intraciliary transport particle A
GO:0032391	photoreceptor connecting cilium
GO:0036064	ciliary basal body
GO:0072372	primary cilium

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024169

View Gene Order

ENSBTAG00000007245

Not yet available

Pathways

NETPATH

REACTOME

REACT_228134

Signaling by Hedgehog pathway

REACT_111102

Signal Transduction pathway

REACT_267634

Hedgehog 'off' state pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.389438

RefSeq

NM_014714 XM_006720989 XM_006720990 XM_006720991 XM_006720992

HUGO

OMIM

CCDS

CCDS10439

HPRD

11093

IMGT

EMBL

GenPept

RNA Seq Atlas