Homo sapiens Gene: EP300
Summary
InnateDB Gene IDBG-8992.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EP300
Gene Name E1A binding protein p300
Synonyms KAT3B; p300; RSTS2;
Species Homo sapiens
Ensembl Gene ENSG00000100393
Encoded Proteins
E1A binding protein p300
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:41091786-41180077
Strand Forward strand
Band q13.2
Transcripts
ENST00000263253 ENSP00000263253
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 721 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
Experimentally validated
Total 721 [view]
Protein-Protein 611 [view]
Protein-DNA 84 [view]
Protein-RNA 0
DNA-DNA 26 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 52 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001159 core promoter proximal region DNA binding
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0003823 antigen binding
GO:0004402 histone acetyltransferase activity
GO:0004468 lysine N-acetyltransferase activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0016407 acetyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0019901 protein kinase binding
GO:0031490 chromatin DNA binding
GO:0032403 protein complex binding
GO:0033613 activating transcription factor binding
GO:0035257 nuclear hormone receptor binding
GO:0035259 glucocorticoid receptor binding
GO:0042975 peroxisome proliferator activated receptor binding
GO:0043425 bHLH transcription factor binding
GO:0046332 SMAD binding
GO:0050681 androgen receptor binding
GO:0051019 mitogen-activated protein kinase binding
GO:0051059 NF-kappaB binding
GO:0097157 pre-mRNA intronic binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0001666 response to hypoxia
GO:0001756 somitogenesis
GO:0001889 liver development
GO:0001934 positive regulation of protein phosphorylation
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006475 internal protein amino acid acetylation
GO:0006915 apoptotic process
GO:0007219 Notch signaling pathway
GO:0007399 nervous system development
GO:0007507 heart development
GO:0007519 skeletal muscle tissue development
GO:0007623 circadian rhythm
GO:0009749 response to glucose
GO:0009887 organ morphogenesis
GO:0010560 positive regulation of glycoprotein biosynthetic process
GO:0010628 positive regulation of gene expression
GO:0010942 positive regulation of cell death
GO:0014070 response to organic cyclic compound
GO:0014737 positive regulation of muscle atrophy
GO:0016032 viral process
GO:0016573 histone acetylation
GO:0018076 N-terminal peptidyl-lysine acetylation
GO:0018393 internal peptidyl-lysine acetylation
GO:0030307 positive regulation of cell growth
GO:0030324 lung development
GO:0031324 negative regulation of cellular metabolic process
GO:0031325 positive regulation of cellular metabolic process
GO:0032025 response to cobalt ion
GO:0032092 positive regulation of protein binding
GO:0032481 positive regulation of type I interferon production
GO:0032526 response to retinoic acid
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0034612 response to tumor necrosis factor
GO:0035690 cellular response to drug
GO:0035984 cellular response to trichostatin A
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0043491 protein kinase B signaling
GO:0043627 response to estrogen
GO:0043923 positive regulation by host of viral transcription
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0043969 histone H2B acetylation
GO:0045087 innate immune response
GO:0045471 response to ethanol
GO:0045727 positive regulation of translation
GO:0045773 positive regulation of axon extension
GO:0045793 positive regulation of cell size
GO:0045862 positive regulation of proteolysis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048565 digestive tract development
GO:0050714 positive regulation of protein secretion
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051592 response to calcium ion
GO:0051726 regulation of cell cycle
GO:0060177 regulation of angiotensin metabolic process
GO:0060298 positive regulation of sarcomere organization
GO:0060548 negative regulation of cell death
GO:0060765 regulation of androgen receptor signaling pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0065004 protein-DNA complex assembly
GO:0070301 cellular response to hydrogen peroxide
GO:0070542 response to fatty acid
GO:0071236 cellular response to antibiotic
GO:0071300 cellular response to retinoic acid
GO:0071320 cellular response to cAMP
GO:0071333 cellular response to glucose stimulus
GO:0071389 cellular response to mineralocorticoid stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071456 cellular response to hypoxia
GO:0071548 response to dexamethasone
GO:0071549 cellular response to dexamethasone stimulus
GO:0090043 regulation of tubulin deacetylation
GO:1901985 positive regulation of protein acetylation
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000629 negative regulation of miRNA metabolic process
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0032993 protein-DNA complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
Notch pathway
KitReceptor pathway
TGF_beta_Receptor pathway
TNFalpha pathway
IL4 pathway
IL6 pathway
Leptin pathway
Prolactin pathway
Oncostatin_M pathway
REACTOME
HATs acetylate histones pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Cellular responses to stress pathway
Developmental Biology pathway
Circadian Clock pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Metabolism of lipids and lipoproteins pathway
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Pre-NOTCH Expression and Processing pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
REV-ERBA represses gene expression pathway
Signaling by Wnt pathway
Signaling by NOTCH1 in Cancer pathway
Innate Immune System pathway
Attenuation phase pathway
TRAF6 mediated IRF7 activation pathway
PPARA activates gene expression pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Signal Transduction pathway
Cell Cycle pathway
Pre-NOTCH Transcription and Translation pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
Signaling by NOTCH2 pathway
RORA activates circadian gene expression pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Immune System pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
TRAF3-dependent IRF activation pathway pathway
Cellular response to hypoxia pathway
HSF1-dependent transactivation pathway
TCF dependent signaling in response to WNT pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Chromatin organization pathway
Signaling by NOTCH pathway
G2/M Transition pathway
Cellular response to heat stress pathway
Factors involved in megakaryocyte development and platelet production pathway
Chromatin modifying enzymes pathway
Signaling by NOTCH1 pathway
Cell Cycle, Mitotic pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Regulation of gene expression by Hypoxia-inducible Factor pathway
formation of the beta-catenin:TCF transactivating complex pathway
Transcriptional regulation of white adipocyte differentiation pathway
NOTCH2 intracellular domain regulates transcription pathway
Mitotic G2-G2/M phases pathway
Metabolism pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Cytosolic sensors of pathogen-associated DNA pathway
Polo-like kinase mediated events pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
Hemostasis pathway
KEGG
Cell cycle pathway
Wnt signaling pathway pathway
Notch signaling pathway pathway
TGF-beta signaling pathway pathway
Adherens junction pathway
Jak-STAT signaling pathway pathway
Long-term potentiation pathway
Melanogenesis pathway
Huntington's disease pathway
Pathways in cancer pathway
Renal cell carcinoma pathway
Prostate cancer pathway
INOH
TGF-beta signaling pathway
BMP2 signaling pathway
Wnt signaling pathway pathway
LIF signaling pathway
Notch signaling pathway pathway
PID BIOCARTA
Hypoxia-inducible factor in the cardivascular system [Biocarta view]
Pelp1 modulation of estrogen receptor activity [Biocarta view]
Mechanism of gene regulation by peroxisome proliferators via ppara [Biocarta view]
Cell cycle: g2/m checkpoint [Biocarta view]
Acetylation and deacetylation of rela in nucleus [Biocarta view]
Role of erbb2 in signal transduction and oncology [Biocarta view]
Control of gene expression by vitamin d receptor [Biocarta view]
Role of ppar-gamma coactivators in obesity and thermogenesis [Biocarta view]
Tgf beta signaling pathway [Biocarta view]
Melanocyte development and pigmentation pathway [Biocarta view]
Role of mef2d in t-cell apoptosis [Biocarta view]
Control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) [Biocarta view]
Hypoxia and p53 in the cardiovascular system [Biocarta view]
Transcription regulation by methyltransferase of carm1 [Biocarta view]
Carm1 and regulation of the estrogen receptor [Biocarta view]
Multi-step regulation of transcription by pitx2 [Biocarta view]
Nfkb activation by nontypeable hemophilus influenzae [Biocarta view]
Erythropoietin mediated neuroprotection through nf-kb [Biocarta view]
Il-7 signal transduction [Biocarta view]
PID NCI
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Validated nuclear estrogen receptor alpha network
ATF-2 transcription factor network
Validated targets of C-MYC transcriptional repression
Notch-mediated HES/HEY network
Regulation of nuclear beta catenin signaling and target gene transcription
AP-1 transcription factor network
p73 transcription factor network
Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class III
Validated transcriptional targets of TAp63 isoforms
Notch signaling pathway
Cross-References
SwissProt Q09472
TrEMBL B5A250
UniProt Splice Variant
Entrez Gene 2033
UniGene Hs.517517 Hs.655211
RefSeq NM_001429
HUGO HGNC:3373
OMIM 602700
CCDS CCDS14010
HPRD 04078
IMGT
EMBL AL035658 AL080243 AL096765 CH471095 EU790779 U01877
GenPept AAA18639 ACF57273 CAH70384 CAH73688 CAI23037 EAW60408
RNA Seq Atlas 2033