InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ST13

Summary

InnateDB Gene

IDBG-8875.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ST13

Gene Name

suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)

Synonyms

AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP; HSPABP1; P48; PRO0786; SNC6

Species

Homo sapiens

Ensembl Gene

ENSG00000100380

Encoded Proteins

IDBP-8877

suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)

IDBP-377825

suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)

IDBP-377828

suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)

IDBP-377829

suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)

IDBP-809867

suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)

IDBP-809871

suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:40824535-40857022

Strand

Reverse strand

Band

q13.2

Transcripts

ENST00000216218	ENSP00000216218
ENST00000455824	ENSP00000397062
ENST00000413424	ENSP00000412049
ENST00000411695	ENSP00000392067
ENST00000480048
ENST00000495652
ENST00000615506	ENSP00000484210
ENST00000620312	ENSP00000481328

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.

Experimentally validated
Total	46 [view]
Protein-Protein	43 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0030544	Hsp70 protein binding
GO:0030674	protein binding, bridging
GO:0032403	protein complex binding
GO:0032564	dATP binding
GO:0042802	identical protein binding
GO:0051082	unfolded protein binding
GO:0051087	chaperone binding

Biological Process

GO:0006457	protein folding
GO:0051260	protein homooligomerization
GO:0061084	negative regulation of protein refolding
GO:0070389	chaperone cofactor-dependent protein refolding

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022403

View Gene Order

ENSBTAG00000006202

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F6VDH7

UniProt Splice Variant

Entrez Gene

6767

UniGene

Hs.511834 Hs.567697 Hs.712713 Hs.713517 Hs.714861

RefSeq

NM_001278589 NM_003932

HUGO

HGNC:11343

OMIM

606796

CCDS

CCDS14006

HPRD

08426

IMGT

EMBL

Z98048

GenPept

RNA Seq Atlas

6767