Homo sapiens Gene: ST13
Summary
InnateDB Gene IDBG-8875.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST13
Gene Name suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
Synonyms AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP; HSPABP1; P48; PRO0786; SNC6;
Species Homo sapiens
Ensembl Gene ENSG00000100380
Encoded Proteins
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:40824535-40857022
Strand Reverse strand
Band q13.2
Transcripts
ENST00000216218 ENSP00000216218
ENST00000455824 ENSP00000397062
ENST00000413424 ENSP00000412049
ENST00000411695 ENSP00000392067
ENST00000480048
ENST00000495652
ENST00000615506 ENSP00000484210
ENST00000620312 ENSP00000481328
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
Experimentally validated
Total 46 [view]
Protein-Protein 43 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0030544 Hsp70 protein binding
GO:0030674 protein binding, bridging
GO:0032403 protein complex binding
GO:0032564 dATP binding
GO:0042802 identical protein binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
Biological Process
GO:0006457 protein folding
GO:0051260 protein homooligomerization
GO:0061084 negative regulation of protein refolding
GO:0070389 chaperone cofactor-dependent protein refolding
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
Ifn alpha signaling pathway [Biocarta view]
PID NCI
Cross-References
SwissProt P50502
TrEMBL B4E0U6 B7ZA40 F6VDH7 Q0IJ56
UniProt Splice Variant
Entrez Gene 6767
UniGene Hs.511834 Hs.567697 Hs.712713 Hs.713517 Hs.714861
RefSeq NM_001278589 NM_003932
HUGO HGNC:11343
OMIM 606796
CCDS CCDS14006
HPRD 08426
IMGT
EMBL AK303530 AK316155 AY513286 BC052982 BC071629 BC121107 BC121108 BC139724 CH471095 CR456586 U17714 U28918 Z98048
GenPept AAB38382 AAC97526 AAH52982 AAH71629 AAI21108 AAI21109 AAI39725 AAT08039 BAG64558 BAH14526 CAB10844 CAG30472 EAW60394
RNA Seq Atlas 6767