Homo sapiens Gene: CRMP1
Summary
InnateDB Gene IDBG-8805.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRMP1
Gene Name collapsin response mediator protein 1
Synonyms CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3;
Species Homo sapiens
Ensembl Gene ENSG00000072832
Encoded Proteins
collapsin response mediator protein 1
collapsin response mediator protein 1
collapsin response mediator protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:5748084-5893058
Strand Reverse strand
Band p16.2
Transcripts
ENST00000324989 ENSP00000321606
ENST00000397890 ENSP00000380987
ENST00000506216
ENST00000511535
ENST00000513911
ENST00000512574 ENSP00000425742
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 105 [view]
Protein-Protein 104 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006208 pyrimidine nucleobase catabolic process
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0048666 neuron development
Cellular Component
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005829 cytosol
GO:0030425 dendrite
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Semaphorin interactions pathway
Axon guidance pathway
CRMPs in Sema3A signaling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL B3KT07 E9PD68 Q96I11
UniProt Splice Variant
Entrez Gene 1400
UniGene Hs.135270 Hs.739348
RefSeq NM_001288661 NM_001014809 NM_001288662 NM_001313
HUGO HGNC:2365
OMIM 602462
CCDS CCDS75102 CCDS33950 CCDS43207
HPRD 03913
IMGT
EMBL AC105915 AK094725 BC007898 CH471131
GenPept AAH07898 BAG52919 EAW82406
RNA Seq Atlas 1400