Version 5.4
Homo sapiens Gene: CRMP1
Summary
InnateDB Gene IDBG-8805.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRMP1
Gene Name collapsin response mediator protein 1
Synonyms CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3
Species Homo sapiens
Ensembl Gene ENSG00000072832
Encoded Proteins
IDBP-8807
collapsin response mediator protein 1
IDBP-234327
collapsin response mediator protein 1
IDBP-473351
collapsin response mediator protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:5748084-5893058
Strand Reverse strand
Band p16.2
Transcripts
ENST00000324989 ENSP00000321606
ENST00000397890 ENSP00000380987
ENST00000506216
ENST00000511535
ENST00000513911
ENST00000512574 ENSP00000425742
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 105 [view]
Protein-Protein 104 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006208 pyrimidine nucleobase catabolic process
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0048666 neuron development
Cellular Component
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005829 cytosol
GO:0030425 dendrite
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029121
View Gene Order
ENSBTAG00000004292
Not yet available
Pathways
NETPATH
REACTOME
REACT_19199
CRMPs in Sema3A signaling pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.135270 Hs.739348
RefSeq NM_001014809 NM_001288661 NM_001288662 NM_001313
HUGO
OMIM
CCDS CCDS33950 CCDS43207 CCDS75102
HPRD 03913
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca