Homo sapiens Gene: TP53BP1
Summary
InnateDB Gene IDBG-8462.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TP53BP1
Gene Name tumor protein p53 binding protein 1
Synonyms 53BP1; p202;
Species Homo sapiens
Ensembl Gene ENSG00000067369
Encoded Proteins
tumor protein p53 binding protein 1
tumor protein p53 binding protein 1
tumor protein p53 binding protein 1
tumor protein p53 binding protein 1
tumor protein p53 binding protein 1
tumor protein p53 binding protein 1
tumor protein p53 binding protein 1
tumor protein p53 binding protein 1
tumor protein p53 binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 15:43403061-43510728
Strand Reverse strand
Band q15.3
Transcripts
ENST00000263801 ENSP00000263801
ENST00000382044 ENSP00000371475
ENST00000382039 ENSP00000371470
ENST00000450115 ENSP00000393497
ENST00000411772 ENSP00000413010
ENST00000434595 ENSP00000416212
ENST00000434561 ENSP00000392048
ENST00000417342 ENSP00000398508
ENST00000413546 ENSP00000388028
ENST00000414758
ENST00000476454
ENST00000467474 ENSP00000471624
ENST00000480860
ENST00000477089
ENST00000572085
ENST00000571145
ENST00000605155
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 162 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 162 [view]
Protein-Protein 160 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0002039 p53 binding
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0035064 methylated histone binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006366 transcription from RNA polymerase II promoter
GO:0006974 cellular response to DNA damage stimulus
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Homologous Recombination Repair pathway
Double-Strand Break Repair pathway
Recruitment of repair and signaling proteins to double-strand breaks pathway
Homologous recombination repair of replication-independent double-strand breaks pathway
DNA Repair pathway
KEGG
INOH
PID BIOCARTA
PID NCI
ATM pathway
Cross-References
SwissProt Q12888
TrEMBL B3KVT9
UniProt Splice Variant
Entrez Gene 7158
UniGene Hs.440968
RefSeq NM_005657 XM_005254634 XM_006720666 NM_001141979 NM_001141980 XM_005254635
HUGO HGNC:11999
OMIM 605230
CCDS CCDS10096 CCDS45250 CCDS45251
HPRD 05569
IMGT
EMBL AB210025 AC018924 AF078776 AK123418 AY904026 BC112161 BX537418 U09477
GenPept AAA21596 AAC62018 AAI12162 AAW69392 BAE06107 BAG53901 CAD97660
RNA Seq Atlas 7158