InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATF4

Summary

InnateDB Gene

IDBG-8409.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATF4

Gene Name

activating transcription factor 4 (tax-responsive enhancer element B67)

Synonyms

CREB-2; CREB2; TAXREB67; TXREB

Species

Homo sapiens

Ensembl Gene

ENSG00000128272

Encoded Proteins

IDBP-8411

activating transcription factor 4 (tax-responsive enhancer element B67)

IDBP-236990

activating transcription factor 4 (tax-responsive enhancer element B67)

IDBP-293390

activating transcription factor 4 (tax-responsive enhancer element B67)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22496230

Murine cytomegalovirus targets transcription factor ATF4 to exploit the unfolded protein response (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 22496230

[Mus musculus] Murine cytomegalovirus targets transcription factor ATF4 to exploit the unfolded protein response

Entrez Gene

Summary

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:39519695-39522685

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000337304	ENSP00000336790
ENST00000396680	ENSP00000379912
ENST00000404241	ENSP00000384587

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	111 [view]
Protein-Protein	101 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046	core promoter sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006094	gluconeogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006520	cellular amino acid metabolic process
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0032922	circadian regulation of gene expression
GO:0034976	response to endoplasmic reticulum stress
GO:0043267	negative regulation of potassium ion transport
GO:0043525	positive regulation of neuron apoptotic process
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0032590	dendrite membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000042406

View Gene Order

ENSBTAG00000017462

Not yet available

Pathways

NETPATH

REACTOME

REACT_18355

ATF4 activates genes pathway

REACT_18277

PERK regulates gene expression pathway

REACT_18423

ATF6-alpha activates chaperone genes pathway

REACT_18348

ATF6-alpha activates chaperones pathway

REACT_18356

Unfolded Protein Response (UPR) pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa04912

GnRH signaling pathway pathway

hsa04010

MAPK signaling pathway pathway

hsa04720

Long-term potentiation pathway

hsa05215

Prostate cancer pathway

hsa04722

Neurotrophin signaling pathway pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

fra_pathway

Validated transcriptional targets of AP1 family members Fra1 and Fra2

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.496487 Hs.634673

RefSeq

NM_001675 NM_182810

HUGO

OMIM

CCDS

CCDS13996

HPRD

06817

IMGT

EMBL

GenPept

RNA Seq Atlas