Homo sapiens Gene: EIF3D
Summary
InnateDB Gene IDBG-5983.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF3D
Gene Name eukaryotic translation initiation factor 3, subunit D
Synonyms eIF3-p66; eIF3-zeta; EIF3S7;
Species Homo sapiens
Ensembl Gene ENSG00000100353
Encoded Proteins
eukaryotic translation initiation factor 3, subunit D
eukaryotic translation initiation factor 3, subunit D
eukaryotic translation initiation factor 3, subunit D
eukaryotic translation initiation factor 3, subunit D
eukaryotic translation initiation factor 3, subunit D
eukaryotic translation initiation factor 3, subunit D
eukaryotic translation initiation factor 3, subunit D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:36510850-36529436
Strand Reverse strand
Band q12.3
Transcripts
ENST00000216190 ENSP00000216190
ENST00000405442 ENSP00000385812
ENST00000402116 ENSP00000385212
ENST00000426531
ENST00000458572 ENSP00000391061
ENST00000455547 ENSP00000390438
ENST00000457241 ENSP00000403584
ENST00000432675 ENSP00000402192
ENST00000478547
ENST00000462641
ENST00000462794
ENST00000496875
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 83 [view]
Protein-Protein 82 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0001732 formation of translation initiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016020 membrane
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Eukaryotic Translation Initiation pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Formation of a pool of free 40S subunits pathway
Translation pathway
Translation initiation complex formation pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Ribosomal scanning and start codon recognition pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Formation of the ternary complex, and subsequently, the 43S complex pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL B0QYA6 B0QYA8
UniProt Splice Variant
Entrez Gene 8664
UniGene Hs.55682
RefSeq NM_003753
HUGO HGNC:3278
OMIM 603915
CCDS CCDS13930
HPRD 04888
IMGT
EMBL AL022313
GenPept
RNA Seq Atlas 8664