Version 5.4
Homo sapiens Gene: EDC3
Summary
InnateDB Gene IDBG-22430.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EDC3
Gene Name enhancer of mRNA decapping 3 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000179151
Encoded Proteins
IDBP-22432
enhancer of mRNA decapping 3 homolog (S. cerevisiae)
IDBP-377750
enhancer of mRNA decapping 3 homolog (S. cerevisiae)
IDBP-745506
IDBP-744881
IDBP-744705
IDBP-745166
IDBP-745533
IDBP-746281
IDBP-744601
IDBP-744529
IDBP-746081
IDBP-747728
IDBP-747239
IDBP-746593
IDBP-746994
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:74630558-74696292
Strand Reverse strand
Band q24.1
Transcripts
ENST00000315127 ENSP00000320503
ENST00000426797 ENSP00000401343
ENST00000569007
ENST00000566119 ENSP00000455682
ENST00000563292 ENSP00000454317
ENST00000568176 ENSP00000455580
ENST00000570138 ENSP00000457170
ENST00000562174 ENSP00000455393
ENST00000566828 ENSP00000455870
ENST00000569561 ENSP00000455589
ENST00000566219 ENSP00000456805
ENST00000569606
ENST00000562047
ENST00000565602 ENSP00000454885
ENST00000562974 ENSP00000457128
ENST00000567813 ENSP00000457156
ENST00000563009 ENSP00000455503
ENST00000566243 ENSP00000457523
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038957
View Gene Order
ENSBTAG00000007308
Not yet available
Pathways
NETPATH
REACTOME
REACT_20518
mRNA decay by 5' to 3' exoribonuclease pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.682454 Hs.96852
RefSeq NM_001142443 NM_001142444 NM_025083
HUGO
OMIM
CCDS CCDS10267
HPRD 07954
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca