Version 5.4
Homo sapiens Gene: SLCO1C1
Summary
InnateDB Gene IDBG-22348.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLCO1C1
Gene Name solute carrier organic anion transporter family, member 1C1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139155
Encoded Proteins
IDBP-22352
solute carrier organic anion transporter family, member 1C1
IDBP-593805
solute carrier organic anion transporter family, member 1C1
IDBP-594580
solute carrier organic anion transporter family, member 1C1
IDBP-602942
solute carrier organic anion transporter family, member 1C1
IDBP-591774
solute carrier organic anion transporter family, member 1C1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:20695355-20753386
Strand Forward strand
Band p12.2
Transcripts
ENST00000266509 ENSP00000266509
ENST00000497911
ENST00000534996
ENST00000539415 ENSP00000437399
ENST00000540354 ENSP00000438665
ENST00000535609
ENST00000545102 ENSP00000444527
ENST00000539443
ENST00000545604 ENSP00000444149
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0043252 sodium-independent organic anion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030235
View Gene Order
ENSBTAG00000019602
Not yet available
Pathways
NETPATH
REACTOME
REACT_23988
Transport of organic anions pathway
REACT_22285
Transport of vitamins, nucleosides, and related molecules pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001145944 NM_001145945 NM_001145946 NM_017435 XM_005253394 XM_005253396
HUGO
OMIM
CCDS CCDS53757 CCDS53758 CCDS53759 CCDS8683
HPRD 08342
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca