InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL6ST

Summary

InnateDB Gene

IDBG-21516.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL6ST

Gene Name

interleukin 6 signal transducer (gp130, oncostatin M receptor)

Synonyms

CD130; CDW130; GP130; IL-6RB

Species

Homo sapiens

Ensembl Gene

ENSG00000134352

Encoded Proteins

IDBP-21518

interleukin 6 signal transducer (gp130, oncostatin M receptor)

IDBP-21520

interleukin 6 signal transducer (gp130, oncostatin M receptor)

IDBP-21522

interleukin 6 signal transducer (gp130, oncostatin M receptor)

IDBP-21524

interleukin 6 signal transducer (gp130, oncostatin M receptor)

IDBP-21526

interleukin 6 signal transducer (gp130, oncostatin M receptor)

IDBP-21528

interleukin 6 signal transducer (gp130, oncostatin M receptor)

IDBP-717695

IDBP-483897

interleukin 6 signal transducer (gp130, oncostatin M receptor)

IDBP-717764

IDBP-590563

interleukin 6 signal transducer (gp130, oncostatin M receptor)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 10829066

IL6ST (GP130) is a common cytokine receptor subunit that is preferentially bound by SOCS3 on its SHP2-binding site, suggesting that some of the negative regulatory roles previously attributed to the phosphatase SHP-2 might in fact be caused by the action of SOCS3.

Entrez Gene

Summary

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2010]
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:55935095-55994993

Strand

Reverse strand

Band

q11.2

Transcripts

ENST00000381298	ENSP00000370698
ENST00000336909	ENSP00000338799
ENST00000381294	ENSP00000370694
ENST00000381293	ENSP00000370693
ENST00000381287	ENSP00000370687
ENST00000381286	ENSP00000370686
ENST00000396816	ENSP00000463896
ENST00000423954
ENST00000503773	ENSP00000426224
ENST00000502326	ENSP00000462158
ENST00000523039
ENST00000522633	ENSP00000435399
ENST00000506241
ENST00000577363
ENST00000583149

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	53 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004897	ciliary neurotrophic factor receptor activity
GO:0004915	interleukin-6 receptor activity
GO:0004921	interleukin-11 receptor activity
GO:0004923	leukemia inhibitory factor receptor activity
GO:0004924	oncostatin-M receptor activity
GO:0005127	ciliary neurotrophic factor receptor binding
GO:0005138	interleukin-6 receptor binding
GO:0005515	protein binding
GO:0019838	growth factor binding
GO:0019970	interleukin-11 binding
GO:0019981	interleukin-6 binding
GO:0042803	protein homodimerization activity
GO:0045509	interleukin-27 receptor activity

Biological Process

GO:0002675	positive regulation of acute inflammatory response
GO:0002821	positive regulation of adaptive immune response
GO:0005977	glycogen metabolic process
GO:0007165	signal transduction
GO:0008284	positive regulation of cell proliferation
GO:0008593	regulation of Notch signaling pathway
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0034097	response to cytokine
GO:0038154	interleukin-11-mediated signaling pathway
GO:0038165	oncostatin-M-mediated signaling pathway
GO:0042102	positive regulation of T cell proliferation
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045669	positive regulation of osteoblast differentiation
GO:0048711	positive regulation of astrocyte differentiation
GO:0048861	leukemia inhibitory factor signaling pathway
GO:0070102	interleukin-6-mediated signaling pathway
GO:0070104	negative regulation of interleukin-6-mediated signaling pathway
GO:0070106	interleukin-27-mediated signaling pathway
GO:0070120	ciliary neurotrophic factor-mediated signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005896	interleukin-6 receptor complex
GO:0005900	oncostatin-M receptor complex
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome
GO:0070110	ciliary neurotrophic factor receptor complex