Homo sapiens Gene: IL6ST
Summary
InnateDB Gene IDBG-21516.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL6ST
Gene Name interleukin 6 signal transducer (gp130, oncostatin M receptor)
Synonyms CD130; CDW130; GP130; IL-6RB;
Species Homo sapiens
Ensembl Gene ENSG00000134352
Encoded Proteins
interleukin 6 signal transducer (gp130, oncostatin M receptor)
interleukin 6 signal transducer (gp130, oncostatin M receptor)
interleukin 6 signal transducer (gp130, oncostatin M receptor)
interleukin 6 signal transducer (gp130, oncostatin M receptor)
interleukin 6 signal transducer (gp130, oncostatin M receptor)
interleukin 6 signal transducer (gp130, oncostatin M receptor)
interleukin 6 signal transducer (gp130, oncostatin M receptor)
interleukin 6 signal transducer (gp130, oncostatin M receptor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL6ST (GP130) is a common cytokine receptor subunit that is preferentially bound by SOCS3 on its SHP2-binding site, suggesting that some of the negative regulatory roles previously attributed to the phosphatase SHP-2 might in fact be caused by the action of SOCS3.
Entrez Gene
Summary The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2010]
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:55935095-55994993
Strand Reverse strand
Band q11.2
Transcripts
ENST00000381298 ENSP00000370698
ENST00000336909 ENSP00000338799
ENST00000381294 ENSP00000370694
ENST00000381293 ENSP00000370693
ENST00000381287 ENSP00000370687
ENST00000381286 ENSP00000370686
ENST00000396816 ENSP00000463896
ENST00000423954
ENST00000503773 ENSP00000426224
ENST00000502326 ENSP00000462158
ENST00000523039
ENST00000522633 ENSP00000435399
ENST00000506241
ENST00000577363
ENST00000583149
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 56 [view]
Protein-Protein 53 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004897 ciliary neurotrophic factor receptor activity
GO:0004915 interleukin-6 receptor activity
GO:0004921 interleukin-11 receptor activity
GO:0004923 leukemia inhibitory factor receptor activity
GO:0004924 oncostatin-M receptor activity
GO:0005127 ciliary neurotrophic factor receptor binding
GO:0005138 interleukin-6 receptor binding
GO:0005515 protein binding
GO:0019838 growth factor binding
GO:0019970 interleukin-11 binding
GO:0019981 interleukin-6 binding
GO:0042803 protein homodimerization activity
GO:0045509 interleukin-27 receptor activity
Biological Process
GO:0002675 positive regulation of acute inflammatory response
GO:0002821 positive regulation of adaptive immune response
GO:0005977 glycogen metabolic process
GO:0007165 signal transduction
GO:0008284 positive regulation of cell proliferation
GO:0008593 regulation of Notch signaling pathway
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0034097 response to cytokine
GO:0038154 interleukin-11-mediated signaling pathway
GO:0038165 oncostatin-M-mediated signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045669 positive regulation of osteoblast differentiation
GO:0048711 positive regulation of astrocyte differentiation
GO:0048861 leukemia inhibitory factor signaling pathway
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway
GO:0070106 interleukin-27-mediated signaling pathway
GO:0070120 ciliary neurotrophic factor-mediated signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005896 interleukin-6 receptor complex
GO:0005900 oncostatin-M receptor complex
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0070062 extracellular vesicular exosome
GO:0070110 ciliary neurotrophic factor receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
IL6 pathway
IL11 pathway
Oncostatin_M pathway
REACTOME
Cytokine Signaling in Immune system pathway
Interleukin-6 signaling pathway
Immune System pathway
Signaling by Interleukins pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
INOH
JAK STAT pathway and regulation pathway
IL-6 signaling pathway
LIF signaling pathway
PID BIOCARTA
PID NCI
IL27-mediated signaling events
SHP2 signaling
IL6-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.462308 Hs.532082 Hs.603484 Hs.605415 Hs.617621 Hs.706627 Hs.708507
RefSeq NM_001190981 NM_002184 NM_175767 XM_005248496
HUGO
OMIM
CCDS CCDS3971 CCDS47209 CCDS54856
HPRD 02824
IMGT
EMBL
GenPept
RNA Seq Atlas