Homo sapiens Gene: HIST4H4
Summary
InnateDB Gene IDBG-21047.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST4H4
Gene Name histone cluster 4, H4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197837
Encoded Proteins
histone cluster 4, H4
histone cluster 4, H4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:14767999-14771131
Strand Reverse strand
Band p12.3
Transcripts
ENST00000358064 ENSP00000350767
ENST00000537096
ENST00000541592
ENST00000537853
ENST00000540565
ENST00000539745 ENSP00000443017
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 157 experimentally validated interaction(s) in this database.
Experimentally validated
Total 157 [view]
Protein-Protein 134 [view]
Protein-DNA 22 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0035575 histone demethylase activity (H4-K20 specific)
GO:0044822 poly(A) RNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000278 mitotic cell cycle
GO:0000723 telomere maintenance
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006335 DNA replication-dependent nucleosome assembly
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006352 DNA-templated transcription, initiation
GO:0034080 centromere-specific nucleosome assembly
GO:0035574 histone H4-K20 demethylation
GO:0045653 negative regulation of megakaryocyte differentiation
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0000228 nuclear chromosome
GO:0000786 nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
HATs acetylate histones pathway
Cellular responses to stress pathway
Packaging Of Telomere Ends pathway
PRC2 methylates histones and DNA pathway
Deposition of new CENPA-containing nucleosomes at the centromere pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNA Polymerase I Transcription pathway
Signaling by WNT in cancer pathway
Condensation of Prophase Chromosomes pathway
HDMs demethylate histones pathway
Signaling by Wnt pathway
Meiotic synapsis pathway
Chromosome Maintenance pathway
Nucleosome assembly pathway
Transcriptional regulation by small RNAs pathway
Epigenetic regulation of gene expression pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
Telomere Maintenance pathway
Signal Transduction pathway
SIRT1 negatively regulates rRNA Expression pathway
Amyloids pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
HDACs deacetylate histones pathway
DNA methylation pathway
M Phase pathway
Cellular Senescence pathway
TCF dependent signaling in response to WNT pathway
Meiotic recombination pathway
Chromatin organization pathway
RNA Polymerase I Promoter Opening pathway
RNA Polymerase I Chain Elongation pathway
Mitotic Prophase pathway
RMTs methylate histone arginines pathway
Chromatin modifying enzymes pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
formation of the beta-catenin:TCF transactivating complex pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Meiosis pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Oxidative Stress Induced Senescence pathway
Gene Expression pathway
Disease pathway
Negative epigenetic regulation of rRNA expression pathway
Regulatory RNA pathways pathway
KEGG
Systemic lupus erythematosus pathway
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by HDAC Class III
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.352191 Hs.737396
RefSeq NM_175054
HUGO
OMIM
CCDS CCDS8665
HPRD 13662
IMGT
EMBL
GenPept
RNA Seq Atlas