Homo sapiens Gene: LIMK1
Summary
InnateDB Gene IDBG-20945.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIMK1
Gene Name LIM domain kinase 1
Synonyms LIMK; LIMK-1;
Species Homo sapiens
Ensembl Gene ENSG00000106683
Encoded Proteins
LIM domain kinase 1
LIM domain kinase 1
LIM domain kinase 1
LIM domain kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:74082933-74122525
Strand Forward strand
Band q11.23
Transcripts
ENST00000336180 ENSP00000336740
ENST00000418310 ENSP00000409717
ENST00000435201 ENSP00000414606
ENST00000486361
ENST00000491052
ENST00000483414
ENST00000476792
ENST00000538333 ENSP00000444452
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 52 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0031072 heat shock protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007266 Rho protein signal transduction
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0009103 lipopolysaccharide biosynthetic process
GO:0030036 actin cytoskeleton organization
GO:0032233 positive regulation of actin filament bundle assembly
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
GO:0045773 positive regulation of axon extension
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0051496 positive regulation of stress fiber assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Leptin pathway
REACTOME
Sema4D in semaphorin signaling pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Developmental Biology pathway
Semaphorin interactions pathway
EPHB-mediated forward signaling pathway
Innate Immune System pathway
Axon guidance pathway
Sema3A PAK dependent Axon repulsion pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
EPH-Ephrin signaling pathway
Sema4D induced cell migration and growth-cone collapse pathway
KEGG
Axon guidance pathway
Fc gamma R-mediated phagocytosis pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
Ccr3 signaling in eosinophils [Biocarta view]
Rho cell motility signaling pathway [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
Role of mal in rho-mediated activation of srf [Biocarta view]
PID NCI
Caspase Cascade in Apoptosis
CXCR4-mediated signaling events
RAC1 signaling pathway
CDC42 signaling events
Cross-References
SwissProt P53667
TrEMBL
UniProt Splice Variant
Entrez Gene 3984
UniGene Hs.647035 Hs.650078
RefSeq NM_001204426 NM_002314
HUGO HGNC:6613
OMIM 601329
CCDS CCDS56491 CCDS5563
HPRD 03210
IMGT
EMBL AC005056 AC005057 AF134379 AK300382 CH471200 D26309 U62293 U63721
GenPept AAB17545 AAB17546 AAC13885 AAC13886 AAD25742 AAS07438 BAA05371 BAH13274 EAW69620 EAW69621 EAW69622 EAW69623
RNA Seq Atlas 3984