InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PTGER4

Summary

InnateDB Gene

IDBG-18106.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGER4

Gene Name

prostaglandin E receptor 4 (subtype EP4)

Synonyms

EP4; EP4R

Species

Homo sapiens

Ensembl Gene

ENSG00000171522

Encoded Proteins

IDBP-18108

prostaglandin E receptor 4 (subtype EP4)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:40679498-40693735

Strand

Forward strand

Band

p13.1

Transcripts

ENST00000302472	ENSP00000302846
ENST00000514343
ENST00000512578
ENST00000509543
ENST00000513635

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004957	prostaglandin E receptor activity
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007254	JNK cascade
GO:0009612	response to mechanical stimulus
GO:0030278	regulation of ossification
GO:0032496	response to lipopolysaccharide
GO:0033624	negative regulation of integrin activation
GO:0042093	T-helper cell differentiation
GO:0045087	innate immune response
GO:0050710	negative regulation of cytokine secretion
GO:0050715	positive regulation of cytokine secretion
GO:0050728	negative regulation of inflammatory response
GO:0050729	positive regulation of inflammatory response
GO:0051492	regulation of stress fiber assembly
GO:0060348	bone development
GO:0070371	ERK1 and ERK2 cascade
GO:0071260	cellular response to mechanical stimulus
GO:2000420	negative regulation of eosinophil extravasation

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000039942

View Gene Order

ENSBTAG00000014972

Not yet available

Pathways

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_18425

Prostanoid ligand receptors pathway

REACT_18352

Eicosanoid ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.199248 Hs.639954

RefSeq

NM_000958

HUGO

OMIM

CCDS

CCDS3930

HPRD

03350

IMGT

EMBL

GenPept

RNA Seq Atlas