Homo sapiens Gene: M6PR
Summary
InnateDB Gene IDBG-17511.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol M6PR
Gene Name mannose-6-phosphate receptor (cation dependent)
Synonyms CD-MPR; MPR 46; MPR-46; MPR46; SMPR;
Species Homo sapiens
Ensembl Gene ENSG00000003056
Encoded Proteins
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
mannose-6-phosphate receptor (cation dependent)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:8940363-8949955
Strand Reverse strand
Band p13.31
Transcripts
ENST00000000412 ENSP00000000412
ENST00000539143 ENSP00000439070
ENST00000541507 ENSP00000442100
ENST00000544193 ENSP00000441040
ENST00000543704 ENSP00000437595
ENST00000537621 ENSP00000444684
ENST00000543258 ENSP00000442983
ENST00000543834
ENST00000544245 ENSP00000439968
ENST00000540837
ENST00000543845 ENSP00000440962
ENST00000543159 ENSP00000441030
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005537 mannose binding
GO:0015578 mannose transmembrane transporter activity
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0007165 signal transduction
GO:0008333 endosome to lysosome transport
GO:0015761 mannose transport
Cellular Component
GO:0000323 lytic vacuole
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
Lysosome Vesicle Biogenesis pathway
Membrane Trafficking pathway
KEGG
Lysosome pathway
Phagosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H0YFY9
UniProt Splice Variant
Entrez Gene 4074
UniGene Hs.134084 Hs.685756
RefSeq NM_001207024 NM_002355 XM_005253376
HUGO HGNC:6752
OMIM 154540
CCDS CCDS73440 CCDS8598
HPRD 01106
IMGT
EMBL AC006581
GenPept
RNA Seq Atlas 4074