Homo sapiens Gene: TCF3
Summary
InnateDB Gene IDBG-14881.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCF3
Gene Name transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
Synonyms bHLHb21; E2A; E47; ITF1; TCF-3; VDIR;
Species Homo sapiens
Ensembl Gene ENSG00000071564
Encoded Proteins
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
transcription factor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:1609290-1652605
Strand Reverse strand
Band p13.3
Transcripts
ENST00000262965 ENSP00000262965
ENST00000344749 ENSP00000344375
ENST00000395423 ENSP00000378813
ENST00000453954 ENSP00000396363
ENST00000585855 ENSP00000465481
ENST00000586318 ENSP00000466954
ENST00000590684 ENSP00000466565
ENST00000586164 ENSP00000467972
ENST00000586410 ENSP00000467388
ENST00000587425 ENSP00000467508
ENST00000588136 ENSP00000468487
ENST00000592395 ENSP00000465251
ENST00000590436 ENSP00000466952
ENST00000590605
ENST00000585731 ENSP00000465510
ENST00000592628 ENSP00000465549
ENST00000587235 ENSP00000466052
ENST00000593064 ENSP00000468481
ENST00000611869 ENSP00000480564
ENST00000610756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 188 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.
Experimentally validated
Total 188 [view]
Protein-Protein 181 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 99 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0035326 enhancer binding
GO:0042803 protein homodimerization activity
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0070491 repressing transcription factor binding
GO:0070644 vitamin D response element binding
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001779 natural killer cell differentiation
GO:0002326 B cell lineage commitment
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0010628 positive regulation of gene expression
GO:0030098 lymphocyte differentiation
GO:0030183 B cell differentiation
GO:0030890 positive regulation of B cell proliferation
GO:0032496 response to lipopolysaccharide
GO:0033077 T cell differentiation in thymus
GO:0033152 immunoglobulin V(D)J recombination
GO:0042493 response to drug
GO:0042692 muscle cell differentiation
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0045666 positive regulation of neuron differentiation
GO:0045787 positive regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048468 cell development
GO:0048541 Peyer's patch development
GO:0050821 protein stabilization
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051149 positive regulation of muscle cell differentiation
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0000788 nuclear nucleosome
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Notch pathway
ID pathway
Wnt pathway
REACTOME
Developmental Biology pathway
CDO in myogenesis pathway
Myogenesis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Notch-mediated HES/HEY network
Regulation of nuclear SMAD2/3 signaling
p38 signaling mediated by MAPKAP kinases
Cross-References
SwissProt
TrEMBL K7EKB9 K7EPS2
UniProt Splice Variant
Entrez Gene 6929
UniGene Hs.371282 Hs.657044 Hs.741355
RefSeq XM_005259620 XM_006722854 XM_006722855 XM_006722857 XM_006722859 XM_006722860 XM_006722863 NM_003200 NM_001136139 XM_006722858 XM_006722856 XM_006722852 XM_006722862 XM_006722861
HUGO HGNC:11633
OMIM 147141
CCDS CCDS12074 CCDS45899
HPRD 00918
IMGT
EMBL AC005321 AC006274
GenPept
RNA Seq Atlas 6929