Homo sapiens Gene: PDS5A
Summary
InnateDB Gene IDBG-14730.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDS5A
Gene Name PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
Synonyms SCC-112; SCC112;
Species Homo sapiens
Ensembl Gene ENSG00000121892
Encoded Proteins
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:39822863-39977956
Strand Reverse strand
Band p14
Transcripts
ENST00000303538 ENSP00000303427
ENST00000507766
ENST00000507020 ENSP00000424510
ENST00000503696
ENST00000503396 ENSP00000426749
ENST00000513798 ENSP00000424531
ENST00000512643 ENSP00000425386
ENST00000503867
ENST00000508625
ENST00000506262
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 53 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007067 mitotic nuclear division
GO:0008156 negative regulation of DNA replication
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Mitotic Telophase/Cytokinesis pathway
S Phase pathway
Separation of Sister Chromatids pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Cohesin Loading onto Chromatin pathway
Cell Cycle, Mitotic pathway
Establishment of Sister Chromatid Cohesion pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q29RF7
TrEMBL B3KMN2 G1UI16 H0Y9L6 H0Y9X6 Q96DB6
UniProt Splice Variant
Entrez Gene 23244
UniGene Hs.331431 Hs.597130 Hs.603808 Hs.607202 Hs.624660 Hs.700053
RefSeq NM_001100399 NM_001100400 XM_005262652
HUGO HGNC:29088
OMIM 613200
CCDS CCDS47045 CCDS54759
HPRD
IMGT
EMBL AB014548 AB621803 AC098591 AC105287 AC113150 AF294791 AK021757 AK098331 AY550968 BC009650 BC041361 BC114218 BC126225 CH471069 CR749425
GenPept AAH09650 AAH41361 AAI14219 AAI26226 AAM82347 AAT52214 BAA31623 BAC05286 BAG51044 BAK64139 CAH18263 EAW92953
RNA Seq Atlas 23244