Version 5.4
Homo sapiens Gene: GATA6
Summary
InnateDB Gene IDBG-1469.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GATA6
Gene Name GATA binding protein 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000141448
Encoded Proteins
IDBP-1471
GATA binding protein 6
IDBP-727742
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21971825
GATA6 activates the transcription of hepcidin antimicrobial peptide in hepatocytes Friend of GATA (FOG)-proteins ZFPM1 and ZFPM2 moderate this transcription by suppressing the GATA transactivation of hepcidin promoter.
InnateDB Annotation from Orthologs
Summary
PMID 21971825
[Mus musculus] Gata6 activates the transcription of hepcidin antimicrobial peptide in hepatocytes. Friend of GATA (FOG)-proteins ZFPM1 and ZFPM2 moderate this transcription by suppressing the GATA transactivation of hepcidin promoter. (Demonstrated in human)
Entrez Gene
Summary This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:22169443-22202528
Strand Forward strand
Band q11.2
Transcripts
ENST00000269216 ENSP00000269216
ENST00000581694 ENSP00000462313
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 7 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0001889 liver development
GO:0003148 outflow tract septum morphogenesis
GO:0003309 type B pancreatic cell differentiation
GO:0003310 pancreatic A cell differentiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006644 phospholipid metabolic process
GO:0007493 endodermal cell fate determination
GO:0007596 blood coagulation
GO:0008584 male gonad development
GO:0010468 regulation of gene expression
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0030855 epithelial cell differentiation
GO:0031016 pancreas development
GO:0032911 negative regulation of transforming growth factor beta1 production
GO:0032912 negative regulation of transforming growth factor beta2 production
GO:0035239 tube morphogenesis
GO:0035987 endodermal cell differentiation
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043627 response to estrogen
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048645 organ formation
GO:0048738 cardiac muscle tissue development
GO:0051145 smooth muscle cell differentiation
GO:0051891 positive regulation of cardioblast differentiation
GO:0055007 cardiac muscle cell differentiation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060430 lung saccule development
GO:0060486 Clara cell differentiation
GO:0060510 Type II pneumocyte differentiation
GO:0060575 intestinal epithelial cell differentiation
GO:0060947 cardiac vascular smooth muscle cell differentiation
GO:0070848 response to growth factor
GO:0071158 positive regulation of cell cycle arrest
GO:0071371 cellular response to gonadotropin stimulus
GO:0071456 cellular response to hypoxia
GO:0071773 cellular response to BMP stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005836
View Gene Order
ENSBTAG00000005734
Not yet available
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
hes_heypathway
Notch-mediated HES/HEY network
Cross-References
SwissProt Q92908
TrEMBL Q05CA6
UniProt Splice Variant
Entrez Gene 2627
UniGene Hs.514746
RefSeq NM_005257
HUGO HGNC:4174
OMIM 601656
CCDS CCDS11872
HPRD 09043
IMGT
EMBL AC091588 BC027891 CH471088 D87811 EF444980 U66075 X95701
GenPept AAC50941 AAH27891 ACA05995 BAA22621 CAA64997 EAX01137
RNA Seq Atlas 2627

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca