Homo sapiens Gene: CFD
Summary
InnateDB Gene IDBG-13129.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CFD
Gene Name complement factor D (adipsin)
Synonyms ADIPSIN; ADN; DF; PFD;
Species Homo sapiens
Ensembl Gene ENSG00000197766
Encoded Proteins
complement factor D (adipsin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:859643-863630
Strand Forward strand
Band p13.3
Transcripts
ENST00000327726 ENSP00000332139
ENST00000592860 ENSP00000468253
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0002576 platelet degranulation
GO:0006508 proteolysis
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0045087 innate immune response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031093 platelet alpha granule lumen
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Alternative complement activation pathway
Innate Immune System pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Immune System pathway
Response to elevated platelet cytosolic Ca2+ pathway
Complement cascade pathway
Initial triggering of complement pathway
Hemostasis pathway
KEGG
Complement and coagulation cascades pathway
Staphylococcus aureus infection pathway
INOH
PID BIOCARTA
Alternative complement pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001928
HUGO
OMIM
CCDS CCDS12046
HPRD 00600
IMGT
EMBL
GenPept
RNA Seq Atlas