Version 5.4
Homo sapiens Gene: CFD
Summary
InnateDB Gene IDBG-13129.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CFD
Gene Name complement factor D (adipsin)
Synonyms ADIPSIN; ADN; DF; PFD
Species Homo sapiens
Ensembl Gene ENSG00000197766
Encoded Proteins
IDBP-13131
complement factor D (adipsin)
IDBP-761976
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:859643-863630
Strand Forward strand
Band p13.3
Transcripts
ENST00000327726 ENSP00000332139
ENST00000592860 ENSP00000468253
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0002576 platelet degranulation
GO:0006508 proteolysis
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0045087 innate immune response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031093 platelet alpha granule lumen
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061780
View Gene Order
ENSBTAG00000048122
Not yet available
Pathways
NETPATH
REACTOME
REACT_8001
Alternative complement activation pathway
REACT_8024
Initial triggering of complement pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_6900
Immune System pathway
REACT_6932
Complement cascade pathway
REACT_604
Hemostasis pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
hsa05150
Staphylococcus aureus infection pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL K7ERG9
UniProt Splice Variant
Entrez Gene 1675
UniGene
RefSeq NM_001928
HUGO HGNC:2771
OMIM 134350
CCDS CCDS12046
HPRD 00600
IMGT
EMBL AC112706
GenPept
RNA Seq Atlas 1675

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca