Homo sapiens Gene: ARAP2
Summary
InnateDB Gene IDBG-13031.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARAP2
Gene Name ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000047365
Encoded Proteins
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:35948221-36244509
Strand Reverse strand
Band p14
Transcripts
ENST00000303965 ENSP00000302895
ENST00000512804
ENST00000503904
ENST00000508066
ENST00000511416 ENSP00000423886
ENST00000506189 ENSP00000422731
ENST00000618163 ENSP00000481036
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by Rho GTPases pathway
Signal Transduction pathway
Rho GTPase cycle pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
Adp-ribosylation factor [Biocarta view]
Rho cell motility signaling pathway [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
PID NCI
Arf6 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.479451 Hs.601941 Hs.629528 Hs.739008
RefSeq NM_015230 XM_005262638 XM_005262642 XM_005262643
HUGO
OMIM
CCDS CCDS3441
HPRD 09439
IMGT
EMBL
GenPept
RNA Seq Atlas