Homo sapiens Gene: DAP
Summary
InnateDB Gene IDBG-12509.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAP
Gene Name death-associated protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112977
Encoded Proteins
death-associated protein
death-associated protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. [provided by RefSeq, Jul 2008]
This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:10679230-10761272
Strand Reverse strand
Band p15.2
Transcripts
ENST00000230895 ENSP00000230895
ENST00000432074 ENSP00000394163
ENST00000514882
ENST00000508253
ENST00000510546
ENST00000508646
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0070513 death domain binding
Biological Process
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010507 negative regulation of autophagy
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034198 cellular response to amino acid starvation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0097190 apoptotic signaling pathway
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt P51397
TrEMBL B4DQ75
UniProt Splice Variant
Entrez Gene 1611
UniGene Hs.75189
RefSeq NM_004394
HUGO HGNC:2672
OMIM 600954
CCDS CCDS3880
HPRD
IMGT
EMBL AC012629 AK298670 AY266680 BC002726 CR542184 X76105
GenPept AAH02726 AAO89078 BAG60837 CAA53713 CAG46981
RNA Seq Atlas 1611