Homo sapiens Gene: SLC34A2
Summary
InnateDB Gene IDBG-12387.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC34A2
Gene Name solute carrier family 34 (sodium phosphate), member 2
Synonyms NAPI-3B; NAPI-IIb; NPTIIb;
Species Homo sapiens
Ensembl Gene ENSG00000157765
Encoded Proteins
solute carrier family 34 (sodium phosphate), member 2
solute carrier family 34 (sodium phosphate), member 2
solute carrier family 34 (sodium phosphate), member 2
solute carrier family 34 (sodium phosphate), member 2
solute carrier family 34 (sodium phosphate), member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:25655301-25678748
Strand Forward strand
Band p15.2
Transcripts
ENST00000382051 ENSP00000371483
ENST00000513204 ENSP00000423038
ENST00000504570 ENSP00000425501
ENST00000503434 ENSP00000423021
ENST00000507530 ENSP00000424266
ENST00000510033
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005436 sodium:phosphate symporter activity
GO:0005524 ATP binding
GO:0015321 sodium-dependent phosphate transmembrane transporter activity
GO:0019904 protein domain specific binding
GO:0031402 sodium ion binding
GO:0042301 phosphate ion binding
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0001701 in utero embryonic development
GO:0006810 transport
GO:0006811 ion transport
GO:0006817 phosphate ion transport
GO:0007568 aging
GO:0009750 response to fructose
GO:0030643 cellular phosphate ion homeostasis
GO:0032355 response to estradiol
GO:0035435 phosphate ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0043627 response to estrogen
GO:0044341 sodium-dependent phosphate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005903 brush border
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0031528 microvillus membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
Type II Na+/Pi cotransporters pathway
Sodium-coupled phosphate cotransporters pathway
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O95436
TrEMBL D6RBC0
UniProt Splice Variant
Entrez Gene 10568
UniGene Hs.479372 Hs.714069
RefSeq NM_006424 NM_001177998 NM_001177999
HUGO HGNC:11020
OMIM 604217
CCDS CCDS3435 CCDS54750
HPRD 07251
IMGT
EMBL AC092436 AF111856 AF146796 AH011306 AK075015 BC142704 BC146666
GenPept AAC98695 AAF31328 AAI42705 AAI46667 AAL55657 BAC11354
RNA Seq Atlas 10568