Homo sapiens Gene: HNRNPA2B1
Summary
InnateDB Gene IDBG-10118.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNRNPA2B1
Gene Name heterogeneous nuclear ribonucleoprotein A2/B1
Synonyms HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1; IBMPFD2; RNPA2; SNRPB1;
Species Homo sapiens
Ensembl Gene ENSG00000122566
Encoded Proteins
heterogeneous nuclear ribonucleoprotein A2/B1
heterogeneous nuclear ribonucleoprotein A2/B1
heterogeneous nuclear ribonucleoprotein A2/B1
heterogeneous nuclear ribonucleoprotein A2/B1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:26189927-26201529
Strand Reverse strand
Band p15.2
Transcripts
ENST00000356674 ENSP00000349101
ENST00000360787 ENSP00000354021
ENST00000354667 ENSP00000346694
ENST00000476233
ENST00000463181
ENST00000490912
ENST00000495810
ENST00000618183 ENSP00000478691
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 174 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 174 [view]
Protein-Protein 169 [view]
Protein-DNA 4 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0043047 single-stranded telomeric DNA binding
GO:0044822 poly(A) RNA binding
GO:0097157 pre-mRNA intronic binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0048025 negative regulation of mRNA splicing, via spliceosome
GO:0050658 RNA transport
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.487774 Hs.597480 Hs.637950 Hs.701179 Hs.701288 Hs.706166
RefSeq NM_002137 NM_031243
HUGO
OMIM
CCDS CCDS43557 CCDS5397
HPRD 02526
IMGT
EMBL
GenPept
RNA Seq Atlas