InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HNRNPA2B1

Summary

InnateDB Gene

IDBG-10118.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPA2B1

Gene Name

heterogeneous nuclear ribonucleoprotein A2/B1

Synonyms

HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1; IBMPFD2; RNPA2; SNRPB1

Species

Homo sapiens

Ensembl Gene

ENSG00000122566

Encoded Proteins

IDBP-10120

heterogeneous nuclear ribonucleoprotein A2/B1

IDBP-10122

heterogeneous nuclear ribonucleoprotein A2/B1

IDBP-10124

heterogeneous nuclear ribonucleoprotein A2/B1

IDBP-811228

heterogeneous nuclear ribonucleoprotein A2/B1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:26189927-26201529

Strand

Reverse strand

Band

p15.2

Transcripts

ENST00000356674	ENSP00000349101
ENST00000360787	ENSP00000354021
ENST00000354667	ENSP00000346694
ENST00000476233
ENST00000463181
ENST00000490912
ENST00000495810
ENST00000618183	ENSP00000478691

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 174 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	174 [view]
Protein-Protein	169 [view]
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0043047	single-stranded telomeric DNA binding
GO:0044822	poly(A) RNA binding
GO:0097157	pre-mRNA intronic binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0048025	negative regulation of mRNA splicing, via spliceosome
GO:0050658	RNA transport

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0071013	catalytic step 2 spliceosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000004980

View Gene Order

ENSBTAG00000005726

Not yet available

Pathways

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_002137 NM_031243

HUGO

OMIM

CCDS

CCDS43557 CCDS5397

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas