InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TCF3

Summary

InnateDB Gene

IDBG-645672.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCF3

Gene Name

transcription factor E2-alpha

Synonyms

TCF7L1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008695

Encoded Proteins

IDBP-698399

transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071564:
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:45599593-45630734

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000028599

ENSBTAP00000028599

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 212 interaction(s) predicted by orthology.

Predicted by orthology
Total	212 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0042803	protein homodimerization activity
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070491	repressing transcription factor binding
GO:0070644	vitamin D response element binding
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001779	natural killer cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0010628	positive regulation of gene expression
GO:0030098	lymphocyte differentiation
GO:0030890	positive regulation of B cell proliferation
GO:0032496	response to lipopolysaccharide
GO:0033077	T cell differentiation in thymus
GO:0033152	immunoglobulin V(D)J recombination
GO:0042493	response to drug
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0045787	positive regulation of cell cycle
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048468	cell development
GO:0048541	Peyer's patch development
GO:0050821	protein stabilization
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:2000045	regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0000788	nuclear nucleosome
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0043234	protein complex