Version 5.4
Bos taurus Gene: M6PR
Summary
InnateDB Gene IDBG-639695.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol M6PR
Gene Name Cation-dependent mannose-6-phosphate receptor
Synonyms CD-MPR; CDMPR
Species Bos taurus
Ensembl Gene ENSBTAG00000018207
Encoded Proteins
IDBP-691880
Cation-dependent mannose-6-phosphate receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000003056:
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:101439877-101452407
Strand Forward strand
Band
Transcripts
ENSBTAT00000024233 ENSBTAP00000024233
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005537 mannose binding
GO:0015578 mannose transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0015761 mannose transport
Cellular Component
GO:0000323 lytic vacuole
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000003056
View Gene Order
ENSMUSG00000007458
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
REACT_209837
Membrane Trafficking pathway
REACT_231722
Lysosome Vesicle Biogenesis pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_234979
Clathrin derived vesicle budding pathway
KEGG
hsa04142
Lysosome pathway
hsa04145
Phagosome pathway
mmu04142
Lysosome pathway
mmu04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt P11456
TrEMBL
UniProt Splice Variant
Entrez Gene 281291
UniGene Bt.5032
RefSeq NM_175779 XM_005207045
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120081 BT029887 M17025
GenPept AAA30634 AAI20082 ABM06137
RNA Seq Atlas 281291

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca