Version 5.4
Bos taurus Gene: BT.67331
Summary
InnateDB Gene IDBG-634947.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.67331
Gene Name Na(+)/H(+) exchange regulatory cofactor NHE-RF2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013479
Encoded Proteins
IDBP-686786
Na(+)/H(+) exchange regulatory cofactor NHE-RF2
IDBP-686788
Na(+)/H(+) exchange regulatory cofactor NHE-RF2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065054:
This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 25:1575649-1589619
Strand Forward strand
Band
Transcripts
ENSBTAT00000065244 ENSBTAP00000055763
ENSBTAT00000049790 ENSBTAP00000046626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
GO:0019902 phosphatase binding
Biological Process
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000065054
View Gene Order
ENSMUSG00000002504
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04960
Aldosterone-regulated sodium reabsorption pathway
mmu04960
Aldosterone-regulated sodium reabsorption pathway
INOH
PID NCI
lysophospholipid_pathway
LPA receptor mediated events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.64994 Bt.67331
RefSeq NM_001077065 XM_005224568 XM_005224570
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca