Version 5.4
Mus musculus Gene: Rxfp2
Summary
InnateDB Gene IDBG-209488.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rxfp2
Gene Name relaxin/insulin-like family peptide receptor 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000053368
Encoded Proteins
IDBP-209490
relaxin/insulin-like family peptide receptor 2
IDBP-260159
relaxin/insulin-like family peptide receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133105:
This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:150018675-150082184
Strand Forward strand
Band G3
Transcripts
ENSMUST00000065745 ENSMUSP00000067897
ENSMUST00000110496 ENSMUSP00000106122
ENSMUST00000143989
ENSMUST00000138901
ENSMUST00000131212
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0016500 protein-hormone receptor activity
GO:0017046 peptide hormone binding
Biological Process
GO:0001556 oocyte maturation
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000133105
View Gene Order
ENSBTAG00000015132
Not yet available
Pathways
NETPATH
REACTOME
REACT_242871
G alpha (s) signalling events pathway
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_231468
GPCR ligand binding pathway
REACT_198713
Relaxin receptors pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_21314
Relaxin receptors pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt Q91ZZ5
TrEMBL
UniProt Splice Variant
Entrez Gene 140498
UniGene Mm.444643
RefSeq NM_080468 XM_006504909 NM_001289564
OMIM
CCDS CCDS19886
HPRD
IMGT
MGI ID MGI:2153463
MGI Symbol Rxfp2
EMBL AC077689 AF346501 BC120741
GenPept AAI20742 AAL08943
RNA Seq Atlas 140498

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca