InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ube3a

Summary

InnateDB Gene

IDBG-190437.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube3a

Gene Name

ubiquitin protein ligase E3A

Synonyms

4732496B02; 5830462N02Rik; A130086L21Rik; Hpve6a; mKIAA4216

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025326

Encoded Proteins

IDBP-266454

ubiquitin protein ligase E3A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114062:
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:59228752-59306727

Strand

Forward strand

Band

Transcripts

ENSMUST00000107537

ENSMUSP00000103161

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 97 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	97 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity

Biological Process

GO:0001541	ovarian follicle development
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016567	protein ubiquitination
GO:0030521	androgen receptor signaling pathway
GO:0035037	sperm entry
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051865	protein autoubiquitination
GO:0060736	prostate gland growth
GO:0070936	protein K48-linked ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000114062

View Gene Order

ENSBTAG00000002487

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

INOH website

Tryptophan degradation pathway

PID NCI

ar_pathway

Coregulation of Androgen receptor activity

telomerasepathway

Regulation of Telomerase

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.420850

RefSeq

NM_001033962 NM_011668 XM_006540798 XM_006540799 XM_006540800 XM_006540801 XM_006540802

OMIM

CCDS

CCDS39973

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas