Version 5.4
Mus musculus Gene: Pim3
Summary
InnateDB Gene IDBG-171915.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pim3
Gene Name proviral integration site 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000035828
Encoded Proteins
IDBP-171917
proviral integration site 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198355:
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:88862186-88865718
Strand Forward strand
Band E3
Transcripts
ENSMUST00000042818 ENSMUSP00000044603
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0009103 lipopolysaccharide biosynthetic process
GO:0016572 histone phosphorylation
GO:0043066 negative regulation of apoptotic process
GO:0046777 protein autophosphorylation
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198355
View Gene Order
ENSBTAG00000045904
Not yet available
Cross-References
SwissProt P58750
TrEMBL Q3TX64
UniProt Splice Variant
Entrez Gene 223775
UniGene Mm.400129 Mm.474725
RefSeq NM_145478
OMIM
CCDS CCDS27734
HPRD
IMGT
MGI ID MGI:1355297
MGI Symbol Pim3
EMBL AK149478 AK159399 AK159600 AK159670 BC017621 BC026639 CH466550
GenPept AAH17621 AAH26639 BAE28905 BAE35052 BAE35220 BAE35274 EDL04393
RNA Seq Atlas 223775

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca